Crystal structure of a CAP-DNA complex: the DNA is bent by 90 degrees

By S. Schultz, G. Shields, T. Steitz. 1991

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

Two-State Allosteric Modeling Suggests Protein Equilibrium as an Integral Component for Cyclic AMP (cAMP) Specificity in the cAMP Receptor Protein of Escherichia coli (2008, background): “The cAMP specificity of wild-type (WT) CRP is consistent with the structure of active CRP, which has been characterized a number of times and shows specific contacts between protein residues and cAMP (27, 29, 33).”
DNA Deformation Energy as an Indirect Recognition Mechanism in Protein-DNA Interactions (2007, background): “All sequences known to bind to IHF [23], CRP [19], [20], I-CreI [21] , I-PpoI [21], and SRF [22] at high affinities were identified from the available literature (see supplemental data).”
An overview of the structures of protein-DNA complexes (2000, unknown): “A2(103-160), B1(5-75), B2(102-161) 1oct C1(5-75) Oct-1 POU domain H.”
Structural basis for cAMP-mediated allosteric control of the catabolite activator protein (2009, background): “The 3D structures of CAP have been determined in its cAMP-bound state (6) and in its cAMP-bound state in complex with DNA (7, 8).”