Segregated Fronto-Cerebellar Circuits Revealed by Intrinsic Functional Connectivity

By Fenna M. Krienen, Randy L. Buckner. Cerebral Cortex, 2009

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Multiple, segregated fronto-cerebellar circuits have been characterized in nonhuman primates using transneuronal tracing techniques including those that target prefrontal areas. Here, we used functional connectivity MRI (fcMRI) in humans (n = 40) to identify 4 topographically distinct fronto-cerebellar circuits that target 1) motor cortex, 2) dorsolateral prefrontal cortex, 3) medial prefrontal cortex, and 4) anterior prefrontal cortex. All 4 circuits were replicated and dissociated in an independent data set (n = 40). Direct comparison of right- and left-seeded frontal regions revealed contralateral lateralization in the cerebellum for each of the segregated circuits. The presence of circuits that involve prefrontal regions confirms that the cerebellum participates in networks important to cognition including a specific fronto-cerebellar circuit that interacts with the default network. Overall, the extent of the cerebellum associated with prefrontal cortex included a large portion of the posterior hemispheres consistent with a prominent role of the cerebellum in nonmotor functions. We conclude by providing a provisional map of the topography of the cerebellum based on functional correlations with the frontal cortex.

Subfields: Cognitive Neuroscience, Neurology, Radiology, Nuclear Medicine and Imaging

View Paper: https://www.semanticscholar.org/paper/4af84fe665a02dc10416c6b2d99735523f7c2934

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Citations in the corpus

The Cerebellum and Cognition: Evidence from Functional Imaging Studies (2011, background): “Importantly, the CCAS can exist in the absence of the cerebellar motor syndrome, depending on the location of the lesion: damage to the anterior lobe is associated with the cerebellar motor syndrome [31, 32], whereas posterior Table 1 Resting-state functional connectivity of cerebro-cerebellar circu”
The cerebellum and cognitive function: 25 years of insight from anatomy and neuroimaging. (2013, background): “Three independent studies examining coupling with cerebral association cortex, including prefrontal regions, all demonstrated that extensive portions of the cerebellum map to association cortex (Habas et al., 2009; Krienen and Buckner, 2009; O’Reilly et al., 2010).”
Identifying major depression using whole-brain functional connectivity: a multivariate pattern analysis. (2012, background): “The cerebellum may contribute to certain non-motor func- tions, including emotion and cognitive processing (Dolan, 1998; Schmahmann and Sherman, 1998; Schmahmann and Caplan, 2006; Hu et al., 2008; Habas et al., 2009; Krienen and Buckner, 2009; O’Reilly et al., 2010; Moulton et al., 2011).”
Consensus Paper: The Cerebellum's Role in Movement and Cognition (2013, background): “In humans, these data have recently been confirmed by MRI and tractography studies [52, 75].”
TRIPLE REPRESENTATION OF LANGUAGE, WORKING MEMORY, SOCIAL AND EMOTION PROCESSING IN THE CEREBELLUM: CONVERGENT EVIDENCE FROM TASK AND SEED-BASED RESTING-STATE FMRI ANALYSES IN A SINGLE LARGE COHORT (2018, background): “, 2012); as well as default-mode network representation in lobule IX (Habas et al., 2009; Krienen and Buckner, 2009; O'Reilly et al., 2010; Buckner et al., 2011) and representation of dorsal attention and frontoparietal networks in lobule X (Buckner et al.”
Functional Topography of the Cerebellum in Verbal Working Memory (2010, background): “Because the inferior cerebellum has been associated with motor control based on evidence of neuroanatomical connections (Kelly and Strick 2003) and resting-state functional connectivity (Krienen and Buckner 2009; O’Reilly et al. 2010) with the primary motor cortex, it is likely that this region supp”
Consensus Paper: Roles of the Cerebellum in Motor Control—The Diversity of Ideas on Cerebellar Involvement in Movement (2011, background): “The cerebellar motor cortex includes the hemispheres of lobules V/VI/VIII, especially their paravermian part, and the anterior vermis [256–259].”
Advances and Pitfalls in the Analysis and Interpretation of Resting-State FMRI Data (2010, positive): “RSNs display reliable and consistent functional connectivity patterns with specifi c thalamic (Zhang et al., 2008) and cerebellar nuclei (Habas et al., 2009; Krienen and Buckner, 2009; O’Reilly et al., 2009).”
Neuroimaging of language control in bilinguals: neural adaptation and reserve (2016, background): “A fronto-cerebellar circuit, for example, links the right cerebellum to the left inferior frontal cortex (Krienen & Buckner, 2009).”
Functional topography of the cerebellum for motor and cognitive tasks: an fMRI study (2011, background): “…lobe and lobule VIII, whereas activity in prefrontal, posterior parietal, and superior and middle temporal association areas, as well as the cingulate gyrus and retrosplenial cortex, correlates with activity in cerebellar lobules VI and VII (Krienen and Buckner, 2009; O'Reilly et al., 2010).”
The role of physiological noise in resting-state functional connectivity (2012, positive): “Sixth, a resting-state functional connectivity study by Krienen and Buckner showed that the left cerebellum was more strongly coupled with the right primary motor cortex, and conversely that the right cerebellum was more strongly coupled with the left motor cortex (Krienen and Buckner, 2009).”
A review and synthesis of the first 20 years of PET and fMRI studies of heard speech, spoken language and reading (2012, background): “…Heim et al., 2009a; de Zubicaray and McMahon, 2009) and this was accompanied by activation in the right vermal and hemispheric components of lobule VI and Crus I and II of lobule VII in the posterior lateral cerebellum (Krienen and Buckner, 2009; Murdoch, 2010; Stoodley and Shamahmann, 2009, 2010).”
Behavioral Interpretations of Intrinsic Connectivity Networks (2011, background): “…2010; Margulies et al., 2009), medial frontal cortex (Kim et al., 2010), cerebellum (O ʼ Reilly, Beckmann, Tomassini, Ramnani, & Johansen-Berg, 2010; Krienen & Buckner, 2009), and insula (Cauda et al., in press; Deen, Pitskel, & Pelphrey, in press). r o Similarly, we aim to investigate the…”
Intrinsic Brain Connectivity in Fibromyalgia is Associated with Chronic Pain Intensity (2010, positive): “Specifically, correlations of the ICN signal on FMRI follow known structural monosynaptic and polysynaptic pathways (10,11), which is likely a reflection of neurophysiologically meaningful activity (12).”