Cgrp May Play A Causative Role in Migraine
By L. Lassen, PA Haderslev, V. Jacobsen, H. Iversen, B. Sperling, J. Olesen. Cephalalgia, 2002
1,005 citations recorded by the source corpus.
Calcitonin gene-related peptide (CGRP) has been detected in increased amounts in external jugular venous blood during migraine attacks. However, it is unknown whether this is secondary to migraine or whether CGRP may cause headache. In a double-blind crossover study, the effect of human αCGRP (2 μg/min) or placebo infused intravenously for 20 min was studied in 12 patients suffering from migraine without aura. Headache intensity was scored on a scale from 0 to 10. Two patients were excluded due to severe hypotension and one because she had an infection. In the first hour median peak headache score was 1.0 in the hαCGRP group vs. 0 in the placebo group (P < 0.01). During the following 11 h all patients experienced headaches after hαCGRP vs. one patient after placebo (P = 0.0004). The median maximal headache score was 4 after CGRP and 0 after placebo (P = 0.006). In three patients after hαCGRP, but in no patients after placebo, the delayed headache fulfilled the IHS criteria for migraine without aura. As intravenous administration of hαCGRP causes headache and migraine in migraineurs, our study suggests that the increase in CGRP observed during spontaneous migraine attacks may play a causative role.
Subfields: Pathology and Forensic Medicine, Psychiatry and Mental health
View Paper: https://www.semanticscholar.org/paper/4ab2e1cf45eb3c108bdca8e84993e637ecd139b9
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In Pathology and Forensic Medicine
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Citations in the corpus
- Pathophysiology of Migraine: A Disorder of Sensory Processing. (2017, methodology): “NO donors, such as glyceryltrinitrate/nitroglycerin, like CGRP (508) and PACAP (720), are used for the experimental induction of migraines (439, 441) and premonitory symptoms (11).”
- Vascular actions of calcitonin gene-related peptide and adrenomedullin. (2004, background): “It is now known that exogenous CGRP induces a delayed migrainelike headache in migraineurs (215), but there is little evidence for a role of CGRP in tension-type headache (11).”
- Calcitonin gene-related peptide: physiology and pathophysiology. (2014, background): “Furthermore, intravenous infusion of CGRP can induce migraine-like attacks in migraine patients (229, 230).”