Expansion of circulating T cells resembling follicular helper T cells is a fixed phenotype that identifies a subset of severe systemic lupus erythematosus.
By N. Simpson, P. Gatenby, Anastasia Wilson, Shreya Malik, D. Fulcher, S. Tangye, H. Manku, T. Vyse, G. Roncador, Gavin A. Huttley and 3 more. Arthritis & Rheumatism, 2010
681 citations recorded by the source corpus.
Subfields: Genetics, Immunology, Rheumatology
View Paper: https://www.semanticscholar.org/paper/4a869e741b7880026789972447c725ce26ff16f0
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In Immunology
Citations in the corpus
- T follicular helper cell differentiation, function, and roles in disease (2014, background): “Increased frequencies of Tfh-like cells (CXCR5+ and PD-1hi or ICOShi) in peripheral blood are observed in subsets of patients with Sjogren’s syndrome (Simpson et al., 2010; Szabo et al., 2013), juvenile dermatomyositis (Morita et al., 2011), and systemic lupus erythematosus (He et al., 2013;…”
- Human Blood CXCR5+CD4+ T Cells Are Counterparts of T Follicular Cells and Contain Specific Subsets that Differentially Support Antibody Secretion (2011, background): “Notably, consistent with a previous report (Simpson et al., 2010), the expression of BCL6 transcript was similar between blood CXCR5+ and CXCR5 Th cell subsets.”
- Human Circulating PD-1+CXCR3−CXCR5+ Memory Tfh Cells Are Highly Functional and Correlate with Broadly Neutralizing HIV Antibody Responses (2013, neutral): “Although it has been suggested that these cells are circulating activated Tfh cells, they do not express elevated amounts of Bcl6 or Maf (Simpson et al., 2010; data not shown), which are central Tfh cell transcription factors required for Tfh cell differen- tiation and function (Crotty, 2011).”