Premature ovarian failure.
By A. Shelling. Reproduction, 2010
1,172 citations recorded by the source corpus.
Premature ovarian failure (POF) is a common cause of infertility in women, and is characterised by amenorrhoea, hypo-oestrogenism and elevated gonadotrophin levels in women under the age of 40. Known causes include iatrogenic agents that cause permanent damage to the ovaries, such as chemotherapy, radiation therapy and surgery, autoimmune conditions, X-chromosome abnormalities and autosomal genetic conditions. However, few genes have been identified that can explain a substantial proportion of cases of POF. Most women with POF are deeply upset by the diagnosis, partly due to the unexpected menopausal symptoms, but also due to infertility. Therefore, early detection would provide better opportunity for early intervention, and furthermore, the identification of specific gene defects will help to direct potential targets for future treatment.
Subfields: Public Health, Environmental and Occupational Health, Reproductive Medicine
View Paper: https://www.semanticscholar.org/paper/4a30357e3beb6b5310c1ea428e4384e310791c8a
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In Public Health, Environmental and Occupational Health
In Reproductive Medicine
Citations in the corpus
- Ovarian aging: mechanisms and clinical consequences. (2009, background): “Thereafter, secondary amenorrhea occurs, associated with estrogen depletion symptoms such as palpitations, heat intolerance, and hot flushes (203, 204).”
- Advance Publication by J-STAGE Japanese Journal of Infectious Diseases Isolation of human coronaviruses OC43, HKU1, NL63, and 229E in Yamagata, Japan, using primary human airway epithelium cells cultured by employing an air-liquid interface culture (2020, neutral): “Thus, reduced ovarian function and infertility result from a declined follicle reserve and/or poor follicular response to the gonadotropins [99].”
- Treatment of Symptoms of the Menopause: An Endocrine Society Clinical Practice Guideline. (2015, background): “The prevalence of POI is approximately 1% (321) and is differentiated into idiopathic, autoimmune (associated with polyglandular autoimmune syndromes), metabolic disorders, and genetic abnormalities (including fragile X premutation).”
- Endocrine-disrupting chemicals: an Endocrine Society scientific statement. (2009, background): “POF (cessation of proper ovarian function before the age of 40) occurs in about 1% of reproductive-age women (72).”