DEFINING THE INTENSITY OF CONDITIONING REGIMENS : working definitions
By A. Bacigalupo, K. Ballen, D. Rizzo, S. Giralt, H. Lazarus, V. Ho, J. Apperley, S. Slavin, M. Pasquini, B. Sandmaier and 4 more. Biology of Blood and Marrow Transplantation, 2009
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SUMMARY Defining conditioning regimen intensity has become a critical issue for the hemopoietic stem cell transplant community. In the present report we propose to define conditioning regimens in three categories: (a) myeloablative conditioning (MA) , (b) reduced intensity conditioning (RIC) and (c) non myeloablative conditioning (NMA). Assignment to these categories is based on the duration of cytopenia and on the requirement for stem cell (SC) support: MA regimens cause irreversible cytopenia and SC support is mandatory. NMA regimens cause minimal cytopenia and can be given also without SC support. RIC regimens do not fit criteria for MA or NMA regimens : they cause cytopenia of variable duration and should be given with stem cell support, although cytopenia may not be irreversible. This report also assigns commonly used regimens to one of these categories. based upon the agents, dose or combinations. Standardized classification of conditioning regimen intensities will allow comparison across studies and interpretation of study results.
Subfields: Hematology, Oncology
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Citations in the corpus
- Umbilical cord blood transplantation: the first 25 years and beyond. (2013, methodology): “In addition, the use of nonmyeloablative or reduced intensity conditioning (RIC), pioneered in related donor and MUD transplantation, allowed older patients and those with comorbidities to be transplanted safely.(44,45) Both of these approaches were combined, initially by the Minnesota group, by usi”
- Intestinal Blautia is associated with reduced death from graft-versus-host disease (2015, methodology): “Conditioning intensity was assigned based on previously established working definitions [22].”