Kainate, a double agent that generates seizures: two decades of progress.

By Yehezkel Ben-Ari, Rosa Cossart. Trends in Neurosciences, 2000

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The endocannabinoid system controls key epileptogenic circuits in the hippocampus. (2006, positive): “We next asked whether the KA-induced increase in inhibitory GABAergic transmission in the hippocampus (Ben-Ari and Cossart, 2000) is influenced by the endocannabinoid system.”
Epigenetic Modulation of Seizure-Induced Neurogenesis and Cognitive Decline (2007, background): “Because KA-induced seizures result in a considerable amount of neuronal cell death (Ben-Ari and Cossart, 2000; Bengzon et al., 2002), we next analyzed whether VPA had a neuroprotective effect after KAinduced seizures, in addition to its inhibition of seizure-induced neurogenesis.”
Medicinal and pharmaceutical uses of seaweed natural products: A review (2004, background): “Kainoids are im- portant tools in research (Higa & Kuniyoshi, 2000) into neurophysiological disorders such as Alzheimer’s and Parkinson’s disease and epilepsy (Ben-Ari & Cossart, 2000; Hopkins et al., 2000; Carcache et al., 2003).”