Applying Adverse Outcome Pathways (AOPs) to support Integrated Approaches to Testing and Assessment (IATA).
By K. Tollefsen, S. Scholz, Mark T. D. Cronin, Stephen W. Edwards, J. D. de Knecht, K. Crofton, N. Garcia-Reyero, T. Hartung, Andrew Paul Worth, Grace Patlewicz. 2014
330 citations recorded by the source corpus.
Chemical regulation is challenged by the large number of chemicals requiring assessment for potential human health and environmental impacts. Current approaches are too resource intensive in terms of time, money and animal use to evaluate all chemicals under development or already on the market. The need for timely and robust decision making demands that regulatory toxicity testing becomes more cost-effective and efficient. One way to realize this goal is by being more strategic in directing testing resources; focusing on chemicals of highest concern, limiting testing to the most probable hazards, or targeting the most vulnerable species. Hypothesis driven Integrated Approaches to Testing and Assessment (IATA) have been proposed as practical solutions to such strategic testing. In parallel, the development of the Adverse Outcome Pathway (AOP) framework, which provides information on the causal links between a molecular initiating event (MIE), intermediate key events (KEs) and an adverse outcome (AO) of regulatory concern, offers the biological context to facilitate development of IATA for regulatory decision making. This manuscript summarizes discussions at the Workshop entitled "Advancing AOPs for Integrated Toxicology and Regulatory Applications" with particular focus on the role AOPs play in informing the development of IATA for different regulatory purposes.
Subfields: Cancer Research, Health, Toxicology and Mutagenesis, Small Animals
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Citations in the corpus
- A strategy for structuring and reporting a read-across prediction of toxicity. (2015, background): “It is recognised that knowledge of an AOP evolves and, as such, AOP development represents a continuum from less-to-more complete with increasing quality, quantification and strength of key events (KEs) and key event relationships (KERs) (Tollefsen et al., 2014).”
- In silico toxicology: computational methods for the prediction of chemical toxicity (2016, neutral): “131 Several projects implement the above approaches.”
- Biology-inspired Microphysiological System Approaches to Solve the Prediction Dilemma of Substance Testing (2016, positive): “There are possibilities to apply in vitro methods, but no accepted alternative methods are available yet for studies on systemic toxicity Strategies (ITS, Hartung et al., 2013b) and Integrated Approaches to Testing and Assessment (IATA, Tollefsen et al., 2014; BalPrice et al., 2015).”
- Adverse outcome pathway (AOP) development I: strategies and principles. (2014, methodology): “html), use of AOPs to support integrated approaches to testing and assessment (Tollefsen et al., 2014), and near term AOP development priorities (Groh et al.”