Absorption, Metabolization, and Antiplatelet Effects of 300-, 600-, and 900-mg Loading Doses of Clopidogrel: Results of the ISAR-CHOICE (Intracoronary Stenting and Antithrombotic Regimen: Choose…

By N. von Beckerath, D. Taubert, G. Pogátsa-Murray, E. Schömig, A. Kastrati, A. Schömig. Circulation, 2005

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Abciximab in patients with acute coronary syndromes undergoing percutaneous coronary intervention after clopidogrel pretreatment: the ISAR-REACT 2 randomized trial. (2006, background): “Recent studies have shown that not only faster but greater platelet inhibition can be achieved by use of a loading dose of 600 mg of clopidogrel as compared with 300 mg.(12,26,27) This has also been associated with better protection from myocardial injury during PCI.”
Management of acute myocardial infarction in patients presenting with persistent ST-segment elevation: the Task Force on the Management of ST-Segment Elevation Acute Myocardial Infarction of the European Society of Cardiology. (2008, background): “It is started with a loading dose of at least 300 mg, but a 600 mg loading dose achieves a more rapid and stronger inhibition of platelet aggregation.(53,54) This should be followed by a daily dose of 75 mg.”