Cortical feedback decorrelates olfactory bulb output in awake mice
By Gonzalo H. Otazu, Honggoo Chae, Martin B. Davis, D. F. Albeanu. 2015
172 citations recorded by the source corpus.
Summary: The olfactory bulb receives rich glutamatergic projections from the piriform cortex. However, the dynamics and importance of these feedback signals remain unknown. Here, we use multiphoton calcium imaging to monitor cortical feedback in the olfactory bulb of awake mice and further probe its impact on the bulb output. Responses of feedback boutons were sparse, odor specific and often outlasted stimuli by several seconds. Odor presentation either enhanced or suppressed the activity of boutons. However, any given bouton responded with stereotypic polarity across multiple odors, preferring either enhancement or suppression. Feedback representations were locally diverse and differed in dynamics across bulb layers. Inactivation of piriform cortex increased odor responsiveness and pairwise similarity of mitral cells, but had little impact on tufted cells. We propose that cortical feedback differentially impacts these two output channels of the bulb by specifically decorrelating mitral cell responses to enable odor separation.
Subfields: Biomedical Engineering, Cellular and Molecular Neuroscience, Sensory Systems
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Citations in the corpus
- Re-evaluating circuit mechanisms underlying pattern separation (2019, positive): “Indeed, recent work in the vertebrate olfactory system has found that removing long-range cortical feedback by inactivating piriform cortex increases the correlation between odour responses in the olfactory bulb (Otazu et al., 2015).”
- Adult-born neurons facilitate olfactory bulb pattern separation during task engagement (2018, unknown): “Consistent with this notion, it has been reported that cortical feedback can decorrelate MC odor representations (Otazu et al., 2015).”