DNA and its associated processes as targets for cancer therapy

By L. Hurley. Nature Reviews. Cancer, 2002

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beta4 integrin-dependent formation of polarized three-dimensional architecture confers resistance to apoptosis in normal and malignant mammary epithelium. (2002, background): “BM-induced tissue polarity is necessary for apoptosis resistance regardless of growth status Cytotoxic drugs induce apoptosis in target cells based upon their capacity to promote cell-cycle arrest (Roninson et al., 2001; Hurley, 2002).”
A review of current nanoparticle and targeting moieties for the delivery of cancer therapeutics (2012, positive): “Doxorubicin has been shown to target the topoisomerase-II-DNA complex, disrupting the DNA and preventing cellular replication (Hurley, 2002).”
Alkylation damage in DNA and RNA--repair mechanisms and medical significance. (2004, background): “In addition, alkylating agents are used as cytostatic drugs in cancer therapy in doses that by far exceed those humans are exposed to from other sources [6].”