PHOTODYNAMIC THERAPY OF CANCER: AN UPDATE

By P. Agostinis, K. Berg, K. Cengel, T. Foster, A. Girotti, S. Gollnick, S. Hahn, Michael R Hamblin, A. Juzeniene, D. Kessel and 7 more. Ca, 2011

4,753 citations recorded by the source corpus.

Photodynamic therapy (PDT) is a clinically approved, minimally invasive therapeutic procedure that can exert a selective cytotoxic activity toward malignant cells. The procedure involves administration of a photosensitizing agent followed by irradiation at a wavelength corresponding to an absorbance band of the sensitizer. In the presence of oxygen, a series of events lead to direct tumor cell death, damage to the microvasculature, and induction of a local inflammatory reaction. Clinical studies revealed that PDT can be curative, particularly in early stage tumors. It can prolong survival in patients with inoperable cancers and significantly improve quality of life. Minimal normal tissue toxicity, negligible systemic effects, greatly reduced long‐term morbidity, lack of intrinsic or acquired resistance mechanisms, and excellent cosmetic as well as organ function‐sparing effects of this treatment make it a valuable therapeutic option for combination treatments. With a number of recent technological improvements, PDT has the potential to become integrated into the mainstream of cancer treatment. CA Cancer J Clin 2011. © 2011 American Cancer Society, Inc.

Subfields: Biomedical Engineering, Cancer Research, Pulmonary and Respiratory Medicine

View Paper: https://www.semanticscholar.org/paper/4929af4c062fcaf19012b44ba8e20fcad9912341

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Biomedical Engineering

1. Fabian Kiessling
2. Zhaochu Yang
3. Tao Dong
4. Michael R Hamblin
5. M. Karimi
6. T. Lammers

In Cancer Research

1. T. Lammers
2. Afshin Samali

In Pulmonary and Respiratory Medicine

1. Michael R Hamblin

Citations in the corpus

• Antimicrobial strategies centered around reactive oxygen species--bactericidal antibiotics, photodynamic therapy, and beyond. (2013, background): “PDT has mostly been developed as a cancer therapy (Agostinis et al., 2011), but recently has been proposed as an antimicrobial therapy (Hamblin & Hasan, 2004).”
• PERK is required at the ER-mitochondrial contact sites to convey apoptosis after ROS-based ER stress (2012, background): “, photosensitizer) to produce detrimental doses of ROS in tumor tissue, leading to its ablation.(7) In previous studies, we found that ROS”
• Photodynamic Therapy Review: Principles, Photosensitizers, Applications, and Future Directions (2021, background): “PDT mechanisms for tumor destruction (based on [12]).”
• Antimicrobial photodynamic inactivation: a bright new technique to kill resistant microbes (2016, background): “aminolevulinic acid), and some time later the tumor would be irradiated with light (either as a surface spot or by insertion of interstitial fiber optics) [4].”
• A novel pathway combining calreticulin exposure and ATP secretion in immunogenic cancer cell death (2012, neutral): “We hypothesized that photodynamic therapy (PDT; Agostinis et al , 2011) might fit the criterion of primary ER-directed ROS production.”