The Relationship Between the Right Ventricle and its Load in Pulmonary Hypertension.
By A. Vonk Noordegraaf, B. Westerhof, N. Westerhof. Journal of the American College of Cardiology, 2017
678 citations recorded by the source corpus.
In pulmonary hypertension, the right ventricle adapts to the increasing vascular load by enhancing contractility ("coupling") to maintain flow. Ventriculoarterial coupling implies that stroke volume changes little while preserving ventricular efficiency. Ultimately, a phase develops where ventricular dilation occurs in an attempt to limit the reduction in stroke volume, with uncoupling and increased wall stress as a consequence. With pressure-volume analysis, we separately describe the changing properties of the pulmonary vascular system and the right ventricle, as well as their coupling, as important concepts for understanding the changes that occur in pulmonary hypertension. On the basis of the unique properties of the pulmonary circulation, we show how all relevant physiological parameters can be derived using an integrative approach. Because coupling is maintained by hypertrophy until the end stage of the disease, when progressive dilation begins, right ventricular volume is the essential parameter to measure in follow-up of patients with pulmonary hypertension.
Subfields: Law
View Paper: https://www.semanticscholar.org/paper/489141746193aaf1347bc322be9f61be541ae35e
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Citations in the corpus
- Anatomy, Function, and Dysfunction of the Right Ventricle: JACC State-of-the-Art Review. (2019, methodology): “Both simplified methods rely on assumptions that may not be equally true in all circumstances (38,39), so further validation is required.”