A cellular mechanism for cortical associations: an organizing principle for the cerebral cortex.

By Matthew E. Larkum. 2013

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In Cognitive Neuroscience

Citations in the corpus

Toward an Integration of Deep Learning and Neuroscience (2016, methodology): “23 This idea has been used by Hawkins and colleagues to suggest mechanisms for continuous online sequence learning (Cui et al., 2015; Hawkins and Ahmad, 2016) and by Larkum and colleagues for comparison of top-down and bottom-up signals (Larkum, 2013).”
Alpha and gamma oscillations characterize feedback and feedforward processing in monkey visual cortex (2014, background): “This finding is of considerable interest because layer 5 cells, thought to be involved in the generation of α (53, 54), are particularly sensitive to coincident input to their basal and apical dendritic trees (55, 56) and their apical dendrites have a resonance in the 5- to 10-Hz frequency range (5,”
Towards deep learning with segregated dendrites (2016, background): “Indeed, framing cortico-cortical feedback as a mechanism to modulate incoming sensory activity is a more common way of viewing feedback signals in the neocortex (Larkum, 2013; Gilbert and Li, 2013; Zhang et al., 2014; Fiser et al., 2016).”
Neural Elements for Predictive Coding (2016, background): “…much promise as a basis for understanding the operations of the cerebral cortex in health (Bastos et al., 2012; Adams et al., 2013a) and disease (Adams et al., 2013b; Lawson et al., 2014) and hence with natural extensions to subcortical loops, too (Kanai et al., 2015; Schwartenbeck et al., 2015).”
Conscious Processing and the Global Neuronal Workspace Hypothesis (2020, background): “…this view, studies that examined tactile perception in mice revealed that it is associated with the reverberation of activity between the frontal cortex and somatosensory cortex that is accompanied by NDMA-receptor-driven calcium events in the distal dendrites of sensory neurons (Larkum, 2013).”
Computing with a Canonical Neural Circuits Model with Pool Normalization and Modulating Feedback (2014, background): “The reproduction of gain enhancement of somatic cortical pyramidal cell responses by coincident input at distal dendritic tufts demonstrates the validity of this generic mechanism (Larkum, 2013).”
Interaction of feedforward and feedback streams in visual cortex in a firing-rate model of columnar computations (2014, background): “Such a modulation can be traced to the level of individual cells where a small network of interconnected neurons builds a cortical association unit of processing (Larkum et al., 1999, Larkum, 2013).”
Dendritic cortical microcircuits approximate the backpropagation algorithm (2018, background): “…bottom-up and top-down synapses converging onto separate dendritic compartments (basal and distal dendrites, respectively), a ﬁrst approximation in line with experimental observations (Spruston, 2008) and reﬂecting the preferred connectivity patterns of cortico-cortical projections (Larkum, 2013).”
Active properties of neocortical pyramidal neuron dendrites. (2013, background): “However, the apical trunk clearly has a special layer-spanning role that signals the output of each dendritic compartment to the others (Larkum et al. 1999, Larkum 2013).”