Pulmonary Vein Denervation Enhances Long-Term Benefit After Circumferential Ablation for Paroxysmal Atrial Fibrillation

By C. Pappone, V. Santinelli, F. Manguso, G. Vicedomini, F. Gugliotta, G. Augello, P. Mazzone, V. Tortoriello, G. Landoni, A. Zangrillo and 5 more. Circulation, 2004

937 citations recorded by the source corpus.

Subfields: Cardiology and Cardiovascular Medicine, Neurology, Physiology

View Paper: https://www.semanticscholar.org/paper/4882668b174abe5972b82b45ecc2526c48a94ee5

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In Cardiology and Cardiovascular Medicine

1. M. Ezekowitz
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Citations in the corpus

• A randomized trial of circumferential pulmonary vein ablation versus antiarrhythmic drug therapy in paroxysmal atrial fibrillation: the APAF Study. (2006, methodology): “Recurrence of T was defined as AT that lasted at least 30 s (5).”
• ACC/AHA/ESC 2006 guidelines for the management of patients with atrial fibrillation--executive summary: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines and the European Society of Cardiology Committee for Practice Guidelines (Writing Commit (2006, neutral): “potentiating initiation and maintenance of AF (161,162), and”
• 2012 HRS/EHRA/ECAS expert consensus statement on catheter and surgical ablation of atrial fibrillation: recommendations for patient selection, procedural techniques, patient management and follow-up, definitions, endpoints, and research trial design (2012, background): “Mild changes in autonomic modulation of the sinus node have been described following ostial PVI as well as circumferential PV ablation [91, 92, 467, 487, 490, 491].”
• Role of the Autonomic Nervous System in Atrial Fibrillation: Pathophysiology and Therapy (2014, background): “Earlier nonrandomized observational studies showed that PV denervation may enhance the long-term outcome of circumferential ablation of PAF.(119) These findings enhanced the theory that hyperactivity of local cardiac ganglionated plexi plays a role in the generation and maintenance of AF.”
• Recovered Pulmonary Vein Conduction as a Dominant Factor for Recurrent Atrial Tachyarrhythmias After Complete Circular Isolation of the Pulmonary Veins: Lessons From Double Lasso Technique (2005, methodology): “(3) Although our patients had highly symptomatic AF before the initial CCLs and asymptomatic short episodes of paroxysmal AF were not documented, it is very difficult to rule out the occurrence of asymptomatic AF in these patients.”
• 2017 HRS/EHRA/ECAS/APHRS/SOLAECE expert consensus statement on catheter and surgical ablation of atrial fibrillation (2017, background): “The latter might include interruption of crucial pathways of conduction between pulmonary-atrial junctions, which play a role in sustenance of AF, reduction of the amount of mass available for the number of simultaneously circulating wavelets (atrial debulking), or partial vagal denervation by inter”