Formulation design for poorly water-soluble drugs based on biopharmaceutics classification system: basic approaches and practical applications.

By Yohei Kawabata, Koichi Wada, M. Nakatani, S. Yamada, S. Onoue. International journal of pharmaceutics, 2011

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Pharmaceutical particle technologies: An approach to improve drug solubility, dissolution and bioavailability (2014, background): “In drug discovery, the number of insoluble drug candidates has increased in recent years, with almost 70% of new drug candidates showing poor water solubility [4].”