Alcoholic fatty liver: its pathogenesis and mechanism of progression to inflammation and fibrosis.

By C. Lieber. Alcohol, 2004

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Liver fibrosis: Pathophysiology, pathogenetic targets and clinical issues. (2019, background): “…cytochrome P450 isoform, leading to acetaldehyde, increased ROS generation and oxidative stress-mediated injury (exacerbated by iron and hypoxia), mainly through lipid peroxidation affecting integrity of mitochondria and ER biomembranes (Lieber, 2004; Gao and Bataller, 2011; Cederbaum, 2012).”
Alcoholic Liver Disease: Pathogenesis and Current Management (2017, background): “Steatosis is the earliest, most common response that develops in more than 90 percent of problem drinkers who consume 4 to 5 standard drinks per day over decades (Ishak et al. 1991; Lieber 2004).”
The role of fructose in the pathogenesis of NAFLD and the metabolic syndrome (2010, background): “These two steps of hepatic injury are similar to those that are caused by ethanol and seen in AFLD”