Multiple mutations and cancer

By Lawrence Loeb, K. Loeb, Jon P. Anderson. Proceedings of the National Academy of Sciences of the United States of America, 2003

771 citations recorded by the source corpus.

Subfields: Cancer Research, Genetics, Pathology and Forensic Medicine

View Paper: https://www.semanticscholar.org/paper/47cc08e8f97b29ea1cfb6e6472fb609d691a46f7

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cancer Research

1. Bert Vogelstein
2. Kenneth W. Kinzler
3. D. J. Barnes
4. J. Melo
5. A. Bardelli
6. L. Diaz

In Genetics

1. Bert Vogelstein
2. D. J. Barnes
3. J. Melo

In Pathology and Forensic Medicine

1. Kenneth W. Kinzler
2. Bert Vogelstein
3. D. J. Barnes
4. J. Melo

Citations in the corpus

• Role of caveolae and caveolins in health and disease. (2004, background): “Indeed, the etiology of most cancers does not reflect alterations in a single gene, but rather the functional loss or induction of a series of key regulatory proteins that, in combination, disrupts the normal regulation of the cell cycle and subsequently leads to uncontrolled cell growth (140).”
• Cancer genes and the pathways they control (2004, background): “If these mutations had to occur simultaneously in a single cell, then the prevalence of cancer would be minima”
• Chronic myeloid leukaemia as a model of disease evolution in human cancer (2007, methodology): “The mutator phenotype hypothesis was first proposed by Loe”