Bone-grafting and bone-graft substitutes.

By C. Finkemeier. Journal of Bone and Joint Surgery. American volume, 2002

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Bone grafts and biomaterials substitutes for bone defect repair: A review (2017, background): “structural integrity andmechanical properties impart that the DBM is mainly applied for filling bone defects [78].”
Bone substitutes in orthopaedic surgery: from basic science to clinical practice (2014, background): “year, with more than 500,000 implanted in the US alone [2–5].”
Sol-gel based materials for biomedical applications (2016, background): “When BGs were implanted, they bind to collagen, growth factors, and fibrin to form a porous matrix to allow infiltration of osteogenic cells [482].”