The Design of Leadlike Combinatorial Libraries.

By S. Teague, A. Davis, Paul D. Leeson, Tudor I. Oprea. 1999

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

1. Ryan G. Coleman
2. Gisbert Schneider
3. Teague Sterling
4. Brian K. Shoichet
5. John J. Irwin
6. Benjamín Sánchez-Lengeling
7. Michael Carchia
8. Sergey I. Nikolenko

Citations in the corpus

• The enumeration of chemical space (2012, background): “These molecules fulfil Lip-inski’s criteria for oral bioavailability 1 as well as lead-likeness 136 and fragment-likeness 137 criteria, mostly because these criteria primarily restrain molecular size.”
• Fragment-based lead discovery (2004, background): “And last, starting the chemical optimization stage with a low-molecular-mass fragment is likely to produce leads whose M r is still within the range desired for lead-likenes”
• Lipophilicity in drug discovery (2010, background): “One possible consequence of this is that lead generation libraries focus on optimal lipophilicity space [8].”