Th1/Th2 balance: the hypothesis, its limitations, and implications for health and disease.

By P. Kidd. Alternative medicine review : a journal of clinical therapeutic, 2003

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Oxidative stress in the pathogenesis of skin disease. (2006, background): “The role of oxidative stress in tumor progression is also supported by the fact that diethylmaleate, a GSH depleter, enhances tumorigenesis, whereas GSH itself or disulfiram, a compound that augments GSH levels, decreases the rate of skin tumor progression (Rotstein and Slaga, 1988).”
The role of oxidative stress in ambient particulate matter-induced lung diseases and its implications in the toxicity of engineered nanoparticles. (2008, background): “Several studies now seem to indicate that oxidative stress is capable of shifting the immune response from Th1 to Th2 dominance [104].”
An immunomodulatory molecule of symbiotic bacteria directs maturation of the host immune system. (2005, background): “SA Is Specifically Recognized by Dendritic Cells, ith Consequent Cell Activation ll CD4+ T cell reactions require instruction to T cells y APCs (Kidd, 2003; Kapsenberg, 2003).”
Glutathione dysregulation and the etiology and progression of human diseases (2009, background): “The Th1 response is overactive in a number of organ-specific autoimmune diseases, including rheumatoid arthritis, type 1 diabetes, and multiple sclerosis; whereas, the Th2 pathway activity is associated with allergy and IgE-based disease, and systemic autoimmunity (Kidd, 2003).”