Decreased collagen production in chronologically aged skin: roles of age-dependent alteration in fibroblast function and defective mechanical stimulation.

By J. Varani, M. Dame, L. Rittié, S. Fligiel, Sewon Kang, G. Fisher, J. Voorhees. American Journal of Pathology, 2006

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Extracellular Matrix and Dermal Fibroblast Function in the Healing Wound (2014, background): “Conversely, the chronically diminished mechanical stimulation imposed by the ECM on dermal fibroblasts has been linked to the reduced production of collagen type I and III and associated dermal laxity characteristic of aging skin.(41) While fibroblasts are Figure 1.”