Annual Report to the Nation on the Status of Cancer, 1975–2011, Featuring Incidence of Breast Cancer Subtypes by Race/Ethnicity, Poverty, and State

By Betsy A Kohler, Recinda L. Sherman, Nadia Howlader, A. Jemal, A. B. Ryerson, Kevin A. Henry, Francis P. Boscoe, Kathleen A. Cronin, Andrew J. Lake, A. Noone and 4 more. Journal of the National Cancer Institute, 2015

1,494 citations recorded by the source corpus.

Background The American Cancer Society (ACS), Centers for Disease Control and Prevention (CDC), National Cancer Institute (NCI), and North American Association of Central Cancer Registries (NAACCR) collaborate annually to produce updated, national cancer statistics. This Annual Report includes a focus on breast cancer incidence by subtype using new, national-level data. Methods Population-based cancer trends and breast cancer incidence by molecular subtype were calculated. Breast cancer subtypes were classified using tumor biomarkers for hormone receptor (HR) and human growth factor-neu receptor (HER2) expression. Results Overall cancer incidence decreased for men by 1.8% annually from 2007 to 2011. Rates for women were stable from 1998 to 2011. Within these trends there was racial/ethnic variation, and some sites have increasing rates. Among children, incidence rates continued to increase by 0.8% per year over the past decade while, like adults, mortality declined. Overall mortality has been declining for both men and women since the early 1990’s and for children since the 1970’s. HR+/HER2− breast cancers, the subtype with the best prognosis, were the most common for all races/ethnicities with highest rates among non-Hispanic white women, local stage cases, and low poverty areas (92.7, 63.51, and 98.69 per 100 000 non-Hispanic white women, respectively). HR+/HER2− breast cancer incidence rates were strongly, positively correlated with mammography use, particularly for non-Hispanic white women (Pearson 0.57, two-sided P < .001). Triple-negative breast cancers, the subtype with the worst prognosis, were highest among non-Hispanic black women (27.2 per 100 000 non-Hispanic black women), which is reflected in high rates in southeastern states. Conclusions Progress continues in reducing the burden of cancer in the United States. There are unique racial/ethnic-specific incidence patterns for breast cancer subtypes; likely because of both biologic and social risk factors, including variation in mammography use. Breast cancer subtype analysis confirms the capacity of cancer registries to adjust national collection standards to produce clinically relevant data based on evolving medical knowledge.

Subfields: Cancer Research, Oncology

View Paper: https://www.semanticscholar.org/paper/47480aafd556c6723f643bcf5a4181110479e1e9

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cancer Research

1. A. Jemal
2. A. Stanisławek
3. Marcin Czeczelewski
4. Sergiusz Łukasiewicz
5. Robert Sitarz
6. J. Baj
7. Alicja Forma

In Oncology

1. A. Jemal
2. Jiemin Ma
3. A. Mariotto
4. R. Siegel
5. K. Miller

Citations in the corpus

• Annual Report to the Nation on the Status of Cancer, 1975–2014, Featuring Survival (2017, methodology): “For most states, population estimates as of July 1 of each year were used to calculate rates that were presumed to reflect the average population of a defined geographic area for a calendar year; however, some adjustments were made to refine these estimates, as has been done in previous reports (16,”
• Breast Cancer—Epidemiology, Risk Factors, Classification, Prognostic Markers, and Current Treatment Strategies—An Updated Review (2021, background): “The expression of human epidermal growth factor receptor 2 (HER2) accounts for approximately 15–25% of breast cancers and its status is primarily relevant in the choice of proper management with breast cancer patients; HER2 overexpression is one of the earliest events during breast carcinogenesis [2”
• Breast cancer statistics 2024 (2024, neutral): “These and age ‐ related differences likely reflect the prevalence of breast cancer risk factors 30 ‐ 32 and mammography use, 33 as well as genetic variation and family history.”
• Worldwide burden of colorectal cancer: a review (2016, background): “The most marked changes occurred in the United States, where CRC incidence rates have declined about 2 to 3 % per year over the last 15 years [7].”
• Annual Report to the Nation on the Status of Cancer, 1975–2012, Featuring the Increasing Incidence of Liver Cancer (2016, neutral): “For most states, population estimates as of July 1 of each year were used to calculate incidence rates, which were presumed to reflect the average population of a defined geographic area for a calendar year; however, some adjustments were made to refine these estimates, as has been done in previous ”