Adipose tissue expandability, lipotoxicity and the Metabolic Syndrome--an allostatic perspective.

By S. Virtue, Antonio Vidal-Puig. Biochimica et Biophysica Acta, 2010

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EDC-2: The Endocrine Society's Second Scientific Statement on Endocrine-Disrupting Chemicals. (2015, background): “The inability of WAT to expand as much as necessary and the development of a dysfunctional adipose tissue contributes to obesity and obesity-associated metabolic complications (183).”
Obesity and female infertility: potential mediators of obesity's impact. (2017, background): “Lipotoxicity plays a role in the development of insulin resistance and a heightened inflammatory state in obese women (40).”
Polycystic ovary syndrome: etiology, pathogenesis and diagnosis (2011, background): “In addition, insulin resistance in PCOS might partially represent dysfunctional adipogenesis from an impaired capacity of regional adipose tissue stores to properly expand with increased dietary caloric intake”