Antithyroid drugs

By B. Goichot, Stephane Vinzio. New England Journal of Medicine, 2005

877 citations recorded by the source corpus.

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The clinical significance of subclinical thyroid dysfunction. (2008, background): “The options for definitive therapy are based on the considerations recommended for overt disease (364, 526).”
Hyperthyroidism and Other Causes of Thyrotoxicosis: Management Guidelines of the American Thyroid Association and American Association of Clinical Endocrinologists (2011, background): “PTU generally has been preferred in pregnancy because of concerns about rare but well-documented teratogenicity associated with MMI, namely, aplasia cutis and choanal or esophageal atresia (81).”
2016 American Thyroid Association Guidelines for Diagnosis and Management of Hyperthyroidism and Other Causes of Thyrotoxicosis (2016, methodology): “FDA to recommended that PTU be reserved for patients who are in their first trimester of pregnancy or who are allergic to or intolerant of MMI (157,470) MMI and PTU both appear in breast milk in only small concentrations, and studies of breastfed infants of mothers taking ATDs have demonstrated norm”
2018 European Thyroid Association Guideline for the Management of Graves’ Hyperthyroidism (2018, background): “PTU at higher doses inhibits deiodination of T4 to T3 [56].”