Metabolomics-Based Methods for Early Disease Diagnostics: A Review
By G. Gowda, Shucha Zhang, Haiwei Gu, Vincent Asiago, Narasimhamurthy Shanaiah, D. Raftery. Expert Review of Molecular Diagnostics, 2008
649 citations recorded by the source corpus.
The emerging field of metabolomics, in which a large number of small-molecule metabolites from body fluids or tissues are detected quantitatively in a single step, promises immense potential for early diagnosis, therapy monitoring and for understanding the pathogenesis of many diseases. Metabolomics methods are mostly focused on the information-rich analytical techniques of NMR spectroscopy and mass spectrometry (MS). Analysis of the data from these high-resolution methods using advanced chemometric approaches provides a powerful platform for translational and clinical research and diagnostic applications. In this review, the current trends and recent advances in NMR- and MS-based metabolomics are described with a focus on the development of advanced NMR and MS methods, improved multivariate statistical data analysis and recent applications in the area of cancer, diabetes, inborn errors of metabolism and cardiovascular diseases.
Subfields: Biomedical Engineering, Molecular Biology, Spectroscopy
View Paper: https://www.semanticscholar.org/paper/468d64f45136ece13b39a9a887b0f0b717b448d2
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Citations in the corpus
- Metabolomics for Investigating Physiological and Pathophysiological Processes. (2019, methodology): “Historically, metabolomics has been primarily used to diagnose diseases or detect pathological conditions (54, 175, 316, 350).”