Mesenchymal Stem Cell Immunomodulation: Mechanisms and Therapeutic potential

By Na Song, Martijn Scholtemeijer, K. Shah. TIPS - Trends in Pharmacological Sciences, 2020

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Mesenchymal stem/stromal cells (MSCs) are multipotent cells that are emerging as the most promising means of allogeneic cell therapy. MSCs have inherent immunomodulatory characteristics, trophic capabilities, high in vitro self-renewal ability, and can be readily engineered to enhance their immune-modulatory functions. MSCs affect the functions of most immune effector cells, via direct contact with immune cells and local microenvironmental factors. Previous studies have confirmed that the immunomodulatory effect of MSCs is mainly communicated via MSC-secreted cytokines; however, apoptotic and metabolically inactivated MSCs have more recently been shown to possess immunomodulatory potential, with regulatory T-cells and monocytes playing a key role. Here we review the immunomodulatory aspects of naïve and engineered MSCs and discuss the strategies of increasing the potential of successfully using MSCs in clinical settings.

Subfields: Biomaterials, Genetics, Surgery

View Paper: https://www.semanticscholar.org/paper/468aa6fe034fa92a4067d498a57625ac7361f627