The way things move: looking under the hood of molecular motor proteins.

By R. Vale, R. Milligan. Science, 2000

1,415 citations recorded by the source corpus.

Subfields: Cardiology and Cardiovascular Medicine, Cell Biology

View Paper: https://www.semanticscholar.org/paper/464977dd949194f5b7bda370eb9767849a90cdcd

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In Cardiology and Cardiovascular Medicine

In Cell Biology

Citations in the corpus

Allostery and cooperativity revisited (2008, background): “Examples include small signaling proteins, various molecular motors (Vale and Milligan 2000), ion pumps (Stokes and Green 2003), and even small ribozymes (Rueda et al. 2004).”
On the accuracy of inferring energetic coupling between distant sites in protein families from evolutionary imprints: Illustrations using lattice model (2009, background): “6 Given the ubiquitous nature of allosteric control in a number of biological processes (movements of motors on polar tracks,7 domain movements in molecular chaperones,8 and enzyme catalysis9), it is important to determine the key residues that are involved in the signalling pathways.”
Single-molecule analysis of dynein processivity and stepping behavior. (2006, background): “In Kinesin1 and myosin V, conformational changes in the lead head-neck linker and lever arm domains, respectively, pull the rear head forward (Vale and Milligan, 2000).”
Ten years of tension: single-molecule DNA mechanics (2003, background): “This enzyme can generate forces exceeding those of cytoskeletal motors that drive transport processes within the cel”
Molecular motor traffic: From biological nanomachines to macroscopic transport (2006, background): “Each head has a single catalytic domain for ATP hydrolysis [35].”
Mechanics of biomolecules (2002, background): “It is highly likely that molecular motors utilize protein conformational changes to store energy, generate motion, and control/regulate motor function (Vale and Milligan, 2000; Kikkawa et al. 2001).”
Integrating protein structural dynamics and evolutionary analysis with Bio3D (2014, background): “Notable examples include the dynamic rearrangements that facilitate many enzyme turnover events [3]; the force producing structural changes of motor proteins [4]; and the conformational and allosteric mechanisms that modulate protein associations in many signal transduction cascades [5,6].”
Striated muscle cytoarchitecture: an intricate web of form and function. (2002, background): “Each myosin head likely repeats this cycle several times in a single twitch (for a review on the detailed structure of the actinmyosin interaction, see Vale & Milligan 2000).”
Stochastic mechano-chemical kinetics of molecular motors: A multidisciplinary enterprise from a physicist’s perspective (2012, background): “In this section we focus on the operational mechanism of a single motor taking into account its architectural design, the energetics of its interaction with the track and that with the fuel molecule, its mechano-chemical kinetic pathways as well as the mechanisms of their regulation and control [19,”