Repetition Suppression and Expectation Suppression Are Dissociable in Time in Early Auditory Evoked Fields

By Ana Todorovic, F. D. de Lange. 2012

319 citations recorded by the source corpus.

Repetition of a stimulus, as well as valid expectation that a stimulus will occur, both attenuate the neural response to it. These effects, repetition suppression and expectation suppression, are typically confounded in paradigms in which the nonrepeated stimulus is also relatively rare (e.g., in oddball blocks of mismatch negativity paradigms, or in repetition suppression paradigms with multiple repetitions before an alternation). However, recent hierarchical models of sensory processing inspire the hypothesis that the two might be separable in time, with repetition suppression occurring earlier, as a consequence of local transition probabilities, and suppression by expectation occurring later, as a consequence of learnt statistical regularities. Here we test this hypothesis in an auditory experiment by orthogonally manipulating stimulus repetition and stimulus expectation and, using magnetoencephalography, measuring the neural response over time in human subjects. We found that stimulus repetition (but not stimulus expectation) attenuates the early auditory response (40–60 ms), while stimulus expectation (but not stimulus repetition) attenuates the subsequent, intermediate stage of auditory processing (100–200 ms). These findings are well in line with hierarchical predictive coding models, which posit sequential stages of prediction error resolution, contingent on the level at which the hypothesis is generated.

Subfields: Cognitive Neuroscience, Experimental and Cognitive Psychology

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Citations in the corpus

An aberrant precision account of autism (2014, unknown): “The implication of these observations is that further studies of repetition (and expectation; Larsson and Smith, 2012; Todorovic and de Lange, 2012) suppression may be especially useful in establishing and quantifying a failure to contextualize or attenuate sensory precision in autism.”
How Prediction Errors Shape Perception, Attention, and Motivation (2012, background): “Below, we will first discuss two main classes of PEs that have been reported in the last decades.”
How Do Expectations Shape Perception? (2018, background): “This is in line with some theoretical models [5] and with observations that putatively predictive phenomena such as extra-classical receptive field effects [5] and expectation suppression [68,96] often occur after the earliest components (>100 ms) of the response.”
Precise minds in uncertain worlds: predictive coding in autism. (2014, background): “…which originates in sensory areas), and stimulus expectations on the basis of more global, integrative and conscious predictions modulating the later P3b novelty response (300-600 ms, originating from a broader frontoparietal predictive network) (Todorovic & de Lange, 2012; Wacongne et al., 2011).”