A detailed ethological analysis of the mouse open field test: effects of diazepam, chlordiazepoxide and an extremely low frequency pulsed magnetic field.

By E. Choleris, A. Thomas, M. Kavaliers, F. Prato. Neuroscience and Biobehavioral Reviews, 2001

740 citations recorded by the source corpus.

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

Individual variation in temporal activity patterns in open-field tests (2010, background): “…abilities (Kalueff et al. 2006), to detect behavioural genetic differences between selected lines (Koolhaas et al. 1999) or strains (Wahlsten et al. 2003; Lalonde & Strazielle 2008), and to examine the effect of drug treatments on behaviour (Corey 1978; Szechtman et al. 1994; Choleris et al. 2001).”
Synchronized activity between the ventral hippocampus and the medial prefrontal cortex during anxiety (2010, neutral): “Percentage of time spent and path length in the center of the open field, as well as percentage of time spent and entries into the open arms of the EPM, were used as pharmacologically validated measures of anxiety-like behavior (Choleris et al., 2001; Lister, 1987).”
Involvement of estrogen receptor α, β and oxytocin in social discrimination: a detailed behavioral analysis with knockout female mice (2006, background): “Stretched approaches, thought to reflect ‘anxiety’ (Blanchard et al. 1993; Choleris et al. 2001; Lister 1990; Rodgers & Dalvi 1997), differed between WT and KO mice, in agreement with previous results (Choleris et al. 2003).”
Measuring behavioral and endocrine responses to novelty stress in adult zebrafish (2010, result): “in a way similar to the rodent open-field test, in which mice or rats show anxiety-like behavior by staying close to the walls (thigmotaxis), but increase exploration of the center as they become less stresse”