On Sensitivity Value of Pair-Matched Observational Studies

By Qingyuan Zhao. Journal of the American Statistical Association, 2017

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ABSTRACT This article proposes a new quantity called the “sensitivity value,” which is defined as the minimum strength of unmeasured confounders needed to change the qualitative conclusions of a naive analysis assuming no unmeasured confounder. We establish the asymptotic normality of the sensitivity value in pair-matched observational studies. The theoretical results are then used to approximate the power of a sensitivity analysis and select the design of a study. We explore the potential to use sensitivity values to screen multiple hypotheses in the presence of unmeasured confounding using a microarray dataset. Supplementary materials for this article are available online.

Subfields: Statistics and Probability

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