Targeting the Hippo pathway in cancer, fibrosis, wound healing and regenerative medicine

By A. Dey, Xaralabos Varelas, K. Guan. Nature reviews. Drug discovery, 2020

706 citations recorded by the source corpus.

The Hippo pathway is an evolutionarily conserved signalling pathway with key roles in organ development, epithelial homeostasis, tissue regeneration, wound healing and immune modulation. Many of these roles are mediated by the transcriptional effectors YAP and TAZ, which direct gene expression via control of the TEAD family of transcription factors. Dysregulated Hippo pathway and YAP/TAZ–TEAD activity is associated with various diseases, most notably cancer, making this pathway an attractive target for therapeutic intervention. This Review highlights the key findings from studies of Hippo pathway signalling across biological processes and diseases, and discusses new strategies and therapeutic implications of targeting this pathway. In this Review, Dey and colleagues discuss the key findings from studies of Hippo pathway signalling across biological processes and diseases, and discuss new strategies and therapeutic implications of targeting this pathway.

Subfields: Cell Biology

View Paper: https://www.semanticscholar.org/paper/45793a19b500ed9def483806f684e601256a6ae7

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In Cell Biology

1. K. Guan
2. David M. Sabatini

Citations in the corpus

• The Hippo signalling pathway and its implications in human health and diseases (2022, background): “At present, the development of potential drugs mainly focuses on three aspects of the Hippo pathway, including Hippo core kinase activity/expression, downstream YAP/TAZ expression levels and YAP/TAZ-TEAD interactions.(7) The Hippo core kinases inhibit YAP/ TAZ to control its location and subsequentl”