Immune regulation by glucocorticoids
By D. Cain, J. Cidlowski. Nature reviews. Immunology, 2017
1,988 citations recorded by the source corpus.
Endogenous glucocorticoids are crucial to various physiological processes, including metabolism, development and inflammation. Since 1948, synthetic glucocorticoids have been used to treat various immune-related disorders. The mechanisms that underlie the immunosuppressive properties of these hormones have been intensely scrutinized, and it is widely appreciated that glucocorticoids have pleiotropic effects on the immune system. However, a clear picture of the cellular and molecular basis of glucocorticoid action has remained elusive. In this Review, we distil several decades of intense (and often conflicting) research that defines the interface between the endocrine stress response and the immune system.
Subfields: Immunology, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/4547379acd1f33d53471021805990a2110aa56ae
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Citations in the corpus
- Rethinking IL-6 and CRP: Why they are more than inflammatory biomarkers, and why it matters. (2018, positive): “More recently, this picture has been complicated by findings suggesting that cortisol may both enhance and suppress inflammation following acute stress, and do so in a time- and concentration-dependent manner (Cain & Cidlowski, 2017; Dhabhar, 2009).”
- Impact of heat stress and nutritional interventions on poultry production (2018, background): “In recent decades, clinical applications of glucocorticoids have outpaced the mechanistic understanding of the immunosuppressive properties, and the research into glucocorticoidmediated regulation of the immune system continues to be an intense field of investigation (Cain and Cidlowski, 2017).”
- Systemic lupus erythematosus: Diagnosis and clinical management. (2019, background): “Corticosteroids affect all components of the immune system [155].”
- Proteomic and Metabolomic Characterization of COVID-19 Patient Sera (2020, positive): “Steroid hormones, including progesterone, androgens, and estrogens can promote the activity of macrophages, as well as other immune cells and non-immune cells (Cain and Cidlowski, 2017).”