Arabidopsis map kinase 4 negatively regulates systemic acquired resistance.

By M. Petersen, P. Brodersen, Henrik Næsted, E. Andreasson, Ursula Lindhart, B. Johansen, H. Nielsen, M. Lacy, M. J. Austin, J. Parker and 6 more. Cell, 2000

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Transposon inactivation of Arabidopsis MAP kinase 4 produced the mpk4 mutant exhibiting constitutive systemic acquired resistance (SAR) including elevated salicylic acid (SA) levels, increased resistance to virulent pathogens, and constitutive pathogenesis-related gene expression shown by Northern and microarray hybridizations. MPK4 kinase activity is required to repress SAR, as an inactive MPK4 form failed to complement mpk4. Analysis of mpk4 expressing the SA hydroxylase NahG and of mpk4/npr1 double mutants indicated that SAR expression in mpk4 is dependent upon elevated SA levels but is independent of NPR1. PDF1.2 and THI2.1 gene induction by jasmonate was blocked in mpk4 expressing NahG, suggesting that MPK4 is required for jasmonic acid-responsive gene expression.

Subfields: Plant Science

View Paper: https://www.semanticscholar.org/paper/4515621a2ef1bb2eb32f9a6f7a08587f7dcd2500

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In Plant Science

Citations in the corpus

Molecular genetic perspectives on cross-talk and specificity in abiotic stress signalling in plants. (2003, background): “The Arabidopsis mutant atmpk4 is insensitive to jasmonic acid, accumulates high levels of salicylic acid and shows constitutive Systemic Acquired Resistance (SAR, Peterson et al., 2000).”
The role of ABA and MAPK signaling pathways in plant abiotic stress responses. (2014, background): “The best studied MAPKs, MPK3, MPK4 and MPK6 have been implicated in plant innate immunity (Asai et al., 2002; Droillard et al., 2004; Petersen et al., 2000), cytokinesis and microtubule organization (Beck et al., 2010, 2011; Kosetsu et al., 2010; Zeng et al., 2011), epidermal patterning (Wang et…”
Direct regulation of the NADPH oxidase RBOHD by the PRR-associated kinase BIK1 during plant immunity. (2014, background): “Notably, the constitutive or inducible overactivation of immunity in a null mutant of an otherwise positive regulator of PTI signaling has been observed before, for example for BAK1 (He et al., 2007; Kemmerling et al., 2007), BIK1 (Zhang et al., 2010), PMR4 (Nishimura et al., 2003), and MPK4 (Peters”
Jasmonates - Signals in Plant-Microbe Interactions (2004, background): “This systemic resistance confers long lasting protection against a broad range of pathogens (Van Loon 2000).”
Phosphorylation of a WRKY Transcription Factor by Two Pathogen-Responsive MAPKs Drives Phytoalexin Biosynthesis in Arabidopsis[C][W] (2011, result): “Our finding that WRKY33 is essential to camalexin biosynthesis is consistent with a previous report (Qiu et al., 2008b). However, more research is needed to reconcile howWRKY33 is regulated. Qiu et al. (2008b) conclude that MPK4 regulates WRKY33 by sequestering it in the MPK4/MKS1 complex in the abs”
WRKY transcription factors: from DNA binding towards biological function. (2004, background): “WRKY-binding sites) within the promoters of a cluster of genes that are co-expressed during systemic acquired resistance [28,29].”
MAP kinase signalling cascade in Arabidopsis innate immunity (2002, neutral): “Protoplasts were expressing GFP, WRKY29 (29), WRKY22 (22) or WRKY42 (42).”