Promoting neuron adhesion and growth
By L. M. Yu, Nic D. Leipzig, M. Shoichet. 2008
168 citations recorded by the source corpus.
During nervous system development, the extracellular matrix (ECM) plays a pivotal role offering anchorage points to maturing neurons and neurites, as well as a permissive environment for tissue formation. Thus enhancement of cell adhesion is often an important criterion when designing biomaterials for neural tissue engineering. In addition to functionalizing biomaterials with ECM-derived cell adhesive molecules, there is emerging evidence that indicates the surface topography, stiffness, and electrical properties play an important role in neuron adhesion and neurite outgrowth. We describe recent developments in biomaterials modification for simulating the microenvironment in order to promote neuron adhesion and growth, as well as to encourage nerve regeneration after injury or disease.
Subfields: Biomedical Engineering, Cell Biology, Cellular and Molecular Neuroscience
View Paper: https://www.semanticscholar.org/paper/44f149164f28ffae021bdfbe6d1749942a561c03
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In Biomedical Engineering
In Cellular and Molecular Neuroscience
Citations in the corpus
- Application of conductive polymers, scaffolds and electrical stimulation for nerve tissue engineering (2011, background): “…conductive polymers by blending conducting polymers with other spinnable polymers, compromising the conductivity of the composite fibres (Yu et al., 2008; Norris et al., 2000; Veluru et al., 2007; Bishop and Gouma, 2005; Desai et al., 2004; Ju et al., 2007; Srivastava et al., 2007; Liu…”