Transcriptional control of effector and memory CD8+ T cell differentiation

By S. Kaech, W. Cui. Nature reviews. Immunology, 2012

1,540 citations recorded by the source corpus.

During an infection, T cells can differentiate into multiple types of effector and memory T cells, which help to mediate pathogen clearance and provide long-term protective immunity. These cells can vary in their phenotype, function and location, and in their long-term fate in terms of their ability to populate the memory T cell pool. Over the past decade, the signalling pathways and transcriptional programmes that regulate the formation of heterogeneous populations of effector and memory CD8+ T cells have started to be characterized, and this Review discusses the major advances in these areas.

Subfields: Immunology

View Paper: https://www.semanticscholar.org/paper/448ab98852784ea43c1550f0fe988d48bf86dfaa

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In Immunology

Citations in the corpus

DE NOVO EPIGENETIC PROGRAMS INHIBIT PD-1 BLOCKADE-MEDIATED T-CELL REJUVENATION (2017, positive): “Antigen-driven clonal expansion and differentiation of naive CD8 T cells initially instills the cells with an effector program that facilitates their ability to directly and indirectly kill antigen-presenting cells (Kaech and Cui, 2012).”
L-Arginine Modulates T Cell Metabolism and Enhances Survival and Anti-tumor Activity (2016, background): “At the end of the immune response, most T cells undergo apoptosis, while a few survive as memory T cells that confer Cell 167, 829–842, Octo This is an open access article under the CC BY-N long-term protection (Kaech and Cui, 2012; Sallusto et al., 2010).”