Cancer and the microbiota

By W. Garrett. Science, 2015

1,278 citations recorded by the source corpus.

A host’s microbiota may increase, diminish, or have no effect at all on cancer susceptibility. Assigning causal roles in cancer to specific microbes and microbiotas, unraveling host-microbiota interactions with environmental factors in carcinogenesis, and exploiting such knowledge for cancer diagnosis and treatment are areas of intensive interest. This Review considers how microbes and the microbiota may amplify or mitigate carcinogenesis, responsiveness to cancer therapeutics, and cancer-associated complications.

Subfields: Biotechnology, Infectious Diseases, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/4473d403b6d6ab785321db8652989b4a3dbb650a

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Citations in the corpus

Role of intestinal microbiota and metabolites on gut homeostasis and human diseases (2017, background): “In addition, manifestations that immunotherapies are displaying efficacy in malignancies of organs such as melanoma, bladder, renal and lung cancers rather than cancer of the colon, the latter being highly-populated by microbes, have garnered extensive attention as to whether and how the microbiota ”
The microbiome and human cancer (2021, background): “Nearly all microbial-based cancer diagnostics are sequencing-based and have focused on tumors within the aerodigestive tract (31), such as colorectal (118–121), pancreatic (122, 123), and lung cancer (124–126).”
The healthy human microbiome (2016, background): “Dysbioses in the microbiome have been associated with numerous diseases, including inflammatory bowel disease, multiple sclerosis, diabetes (types 1 and 2), allergies, asthma, autism, and cancer [1–5].”
Small Molecules from the Human Microbiota (2015, neutral): “1016/0092-8674(90)90497-3; pmid: 1701694 50.”
Fusobacterium nucleatum Promotes Chemoresistance to Colorectal Cancer by Modulating Autophagy (2017, background): “The microbiota is linked to CRC initiation and progression via affecting intestinal inflammation (Arthur et al., 2012; Garrett, 2015; Man et al., 2015; Zitvogel et al., 2015) and tumor-related signaling pathways (Schwabe and Jobin, 2013).”
Cellular Senescence: Aging, Cancer, and Injury. (2019, background): “The microbiota and its associated metabolism are fundamental to a number of physiological functions and imbalances in the bacterial community, termed dysbiosis, have been described and correlated to a number of pathological situations, including cancer (134).”
Fusobacterium nucleatum in colorectal carcinoma tissue and patient prognosis (2015, methodology): “Test for a linear trend was conducted across the ordinal categories (negative [0], low [1], and high [2]) of the amount of tissue Fusobacterium nucleatum DNA as a continuous variable in logistic regression models.”
Fap2 Mediates Fusobacterium nucleatum Colorectal Adenocarcinoma Enrichment by Binding to Tumor-Expressed Gal-GalNAc (2016, background): “…cancer (CRC) is the third leading cause of cancer-related deaths in the United States (Siegel et al., 2015), and microbes have emerged as key factors that influence the development, progression, and response to treatment of CRC (Garrett, 2015; Sears and Garrett, 2014; Thomas and Jobin, 2015).”
Resistance Mechanisms to Immune-Checkpoint Blockade in Cancer: Tumor-Intrinsic and -Extrinsic Factors. (2016, neutral): “Although the composition of microbial communities is generally stable within each individual (Gophna, 2011), there exists a vast level of inter-individual heterogeneity (even between identical twins; Turnbaugh et al., 2009a) that is largely determined by the diet (Turnbaugh et al., 2009b; Wu et…”