Atomic Biology, Electrostatics, and Ionic Channels
By Robert S. Eisenberg. 2008
87 citations recorded by the source corpus.
I believe an atomic biology is needed to supplement present day molecular biology, if we are to design and understand proteins, as well as define, make, and use them. Topics in the paper are molecular biology and atomic biology. Electrodiffusion in the open channel. Electrodiffusion in mixed electrolytes. Models of permeation. State Models of Permeation are Inconsistent with the Electric Field. Making models in atomic biology. Molecular dynamics. Temporal Limitations; Spatial Limitations; Periodic boundary conditions. Hierarchy of models of the open channel. Stochastic Motion of the Channel. Langevin Dynamics. Simulations of the Reaction Path: the Permion. Chemical reactions. What was wrong? Back to the hierarchy: Occam's razor can slit your throat. Poisson-Nernst-Planck PNP Models Flux Ratios; Pumping by Field Coupling. Gating in channels of one conformation. Gating by Field Switching; Gating Current; Gating in Branched Channels; Blocking. Back to the hierarchy: Linking levels. Is there a theory? At what level will the adaptation be found? Simplicity, evolution, and natural function.
Subfields: Astronomy and Astrophysics, Atomic and Molecular Physics, and Optics, Statistical and Nonlinear Physics
View Paper: https://www.semanticscholar.org/paper/447072b5c2581e82837093101a8dc2804025d209
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Citations in the corpus
- One-dimensional steady-state Poisson–Nernst–Planck systems for ion channels with multiple ion species (2009, unknown): “D-VTBTB, Eis, Eis1, Eis2, Eis3, Eis4 , Eis5, Hen, Lun, MM, Rou, Sel]).”
- A new approach to the Lennard-Jones potential and a new model: PNP-steric equations (2014, background): “Instability is of great interest because it may be related to the spontaneous gating phenomena seen whenever currents through single ion channels are measured [13, 43, 44, 49].”