High-throughput sequencing of the paired human immunoglobulin heavy and light chain repertoire

By B. DeKosky, G. Ippolito, Ryan P Deschner, Jason J. Lavinder, Y. Wine, Brandon M. Rawlings, N. Varadarajan, C. Giesecke, T. Dörner, Sarah F. Andrews and 5 more. 2013

425 citations recorded by the source corpus.

Subfields: Immunology, Radiology, Nuclear Medicine and Imaging

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

1. Jeffrey J. Gray
2. Adam J. Riesselman
3. Christopher Sander
4. Jung-Eun Shin
5. Aaron W. Kollasch
6. Elana Simon
7. A. Manglik
8. Debora Marks

In Radiology, Nuclear Medicine and Imaging

1. Jeffrey J. Gray
2. Daisuke Kuroda
3. Adam J. Riesselman
4. Christopher Sander
5. Jung-Eun Shin
6. Aaron W. Kollasch
7. Elana Simon
8. A. Manglik

Citations in the corpus

• Protein design and variant prediction using autoregressive generative models (2021, background): “Paired antibody chains are more challenging to sequence than nanobodies, but more repertoires are becoming available 91 .”
• Large-scale sequence and structural comparisons of human naive and antigen-experienced antibody repertoires (2016, methodology): “MiSeq 2 × 300 technology permits sequencing 600 bp of the ∼850-bp VH:VL amplicon per sample, and therefore full-length VH and VL genes for AEBCs were generated via bioinformatic assembly of the separate VH, VL, and VH:VL sequencing samples as described previously (29, 30, 33, 34).”