PDMS absorption of small molecules and consequences in microfluidic applications.

By M. W. Toepke, David J. Beebe. Lab on a Chip, 2006

1,101 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/443921cc177286b0af33f85b3d0b872ca6f35ccc

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In Biomedical Engineering

Citations in the corpus

Multisensor-integrated organs-on-chips platform for automated and continual in situ monitoring of organoid behaviors (2017, background): “First, the material for making the microfluidic chips was PDMS at this prototyping stage, which is not optimal for organs-on-chip applications due to their potential adsorption and absorption of hydrophobic small molecules and drugs (65, 66).”
3D Self-Organized Microvascular Model of the Human Blood-Brain Barrier with Endothelial Cells, Pericytes and Astrocytes (2018, background): “Although PDMS is widely used for microfluidic applications, one of its disadvantages is non-specific adsorption of proteins and small hydrophobic molecules during long-term interaction [67].”
PDMS-Based Microfluidic Devices for Cell Culture (2018, background): “A reverse consideration should be done if we consider that PDMS is hydrophobic and could induce the absorption of several small and hydrophobic molecules involved in cell microenvironments [71].”
Properties and Applications of PDMS for Biomedical Engineering: A Review (2021, background): “In some applications, the absorption of small molecules flowing through the channels makes it difficult to quantitatively analyse experiments in proteomic drug discovery and cell culture [67,68].”
Advantages and challenges of microfluidic cell culture in polydimethylsiloxane devices. (2015, background): “It has been demonstrated that Nile Red, a small hydrophobic fluorescent dye, is absorbed into PDMS surrounding a microfluidic channel in a matter of seconds, and the fluorescent signal was retained in the PDMS despite multiple washes (Toepke and Beebe, 2006).”