Tracking cancer drugs in living cells by thermal profiling of the proteome

By Mikhail M. Savitski, Friedrich B M Reinhard, Holger Franken, Thilo Werner, Maria Fälth Savitski, D. Eberhard, D. M. Molina, R. Jafari, R. Dovega, Susan Klaeger and 4 more. Science, 2014

1,059 citations recorded by the source corpus.

Subfields: Molecular Biology, Radiology, Nuclear Medicine and Imaging, Spectroscopy

View Paper: https://www.semanticscholar.org/paper/4402f53934f57691426c289529ba4963ae9dee7b

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Molecular Biology

1. J. Dauparas
2. Mathias Wilhelm
3. B. Kuster
4. Sergey Ovchinnikov
5. Hannes Hahne
6. S. Schneider
7. N. Mangan
8. David Baker

In Spectroscopy

1. Mathias Wilhelm
2. B. Kuster
3. Sergey Ovchinnikov
4. Hannes Hahne

Citations in the corpus

• Mega-scale experimental analysis of protein folding stability in biology and design (2023, background): “Compared with mass spectrometry-based high-throughput stability assays 16,17 , cDNA display proteolysis achieves a 100-fold larger scale and can easily be applied to study mutational libraries that pose difficulties for proteomics.”
• Natural Products for Drug Discovery in the 21st Century: Innovations for Novel Drug Discovery (2018, background): “By identifying off-targets TPP can be used to study possible side effects of candidate drug compounds [150].”
• The target landscape of clinical kinase drugs (2017, background): “Recent reports have shown that KIs can bind the enzyme FECH and that inhibition of FECH is the mechanism by which the clinically observed photosensitivity of vemurafenib patients can be rationalized (38, 39).”