Drug discovery from natural sources

By Y. Chin, Marcy J. Balunas, H. Chai, A. Kinghorn. AAPS Journal, 2006

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Biology of Endophytic Fungi (2012, background): “…organisms that are well known for producing many novel metabolites which are directly used as drugs or function as lead structures for synthetic modifications (Kock et al. 2001, Bode et al. 2002, Donadio et al. 2002, Chin et al. 2006, Gunatilaka 2006, Mitchell et al. 2008, Stadler & Keller 2008).”
A Historical Overview of Natural Products in Drug Discovery (2012, methodology): “Halichondrin B (55) has been successfully synthesized [118] along with several structural analogues including Halichondrin E-7389 (56) which has been selected for further development and is currently in phase III clinical trials for the treatment of breast carcinoma (Figure 15) [113].”
Antarctic marine chemical ecology: what is next? (2008, background): “Currently, with more than 18,000 compounds described (MarinLit database), the field of marine natural products has grown and developed, and actually many compounds are under clinical trials to be used as drugs (e.g. Newman & Cragg 2004; Salomon et al. 2004; Chin et al. 2006).”
Fungal endophytes and bioprospecting (2009, background): “metabolic diseases and immunological and genetic disorders were brought to the market (Chin et al. 2006).”