Murine Leukemia Induced by Retroviral Gene Marking

By Zhixiong Li, J. Düllmann, B. Schiedlmeier, M. Schmidt, C. von Kalle, Johann Meyer, Martin D. Forster, C. Stocking, A. Wahlers, O. Frank and 5 more. Science, 2002

673 citations recorded by the source corpus.

Subfields: Genetics, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/43816a2af0a37500cbc0eec14533dadfd7673621

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Citations in the corpus

Correction of X-linked chronic granulomatous disease by gene therapy, augmented by insertional activation of MDS1-EVI1, PRDM16 or SETBP1 (2006, background): “The Mds1-Evi1 gene locus also is a common target for tumorigenesis produced by wild-type retrovirus or retrovirus vector–induced insertional mutagenesis, a process that involves multiple genetic mutation”
Genomic instability and myelodysplasia with monosomy 7 consequent to EVI1 activation after gene therapy for chronic granulomatous disease (2010, background): “In mouse hematopoiesis, the insertional activation of Evi1 can also lead to leukemia of myeloid or lymphoid origi”
Retroviral DNA Integration: ASLV, HIV, and MLV Show Distinct Target Site Preferences (2004, background): “Insertional activation of oncogenes by retroviral vectors has also been detected in animal models (Li et al. 2002).”
Progress and problems with the use of viral vectors for gene therapy (2003, background): “One study showed that the transplantation and expansion of a clone of retrovirally transduced bone-marrow cells had induced leukaemia in mic”