Dental biofilms: difficult therapeutic targets.

By S. Socransky, A. Haffajee. Periodontology 2000, 2002

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Composition of the adult digestive tract bacterial microbiome based on seven mouth surfaces, tonsils, throat and stool samples (2012, background): “An estimated 10(11) bacterial cells per day flow from the mouth to the stomach [78,79].”
Periodontal microbial ecology. (2005, background): “From these studies and others detailed in (155), the putative steps in the development of intraoral biofilms have been postulated as outlined in Fig.”
Oral Biofilm Architecture on Natural Teeth (2010, background): “Oral microbial biofilms are three-dimensional structured bacterial communities [1] attached to a solid surface like the enamel of the teeth, the surface of the root or dental implants [2] and are embedded in an exo-polysaccharide matrix [3].”
A Global Perspective on Microplastics (2020, background): “Biofilm inhabitants also excrete chemical cues that affect invertebrate recruitment and forms of metabolic cooperation (e.g., quorum sensing; Socransky & Haffajee, 2002; Zhang et al., 2019).”