Contemporary Epidemiology of Chronic Liver Disease and Cirrhosis

By A. Moon, Amit G. Singal, E. Tapper. Clinical Gastroenterology and Hepatology, 2019

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Background: Accurate estimates for the contemporary burden of chronic liver disease (CLD) are vital for setting clinical, research, and policy priorities. We aimed to review the incidence, prevalence, and mortality of CLD and its resulting complications, including cirrhosis and hepatocellular carcinoma (HCC). Findings: The epidemiology of CLD is shifting, reflecting implementation of large-scale hepatitis B vaccination and hepatitis C treatment programs, the rising prevalence of the metabolic syndrome, and increasing alcohol misuse. In this setting, data from the Centers for Disease Control and the Global Burden of Disease Study demonstrate the incidence and clinical impact of CLD and its complications continue to rise worldwide. We conclude by discussing limitations of available data and outline steps on improving data infrastructure. Conclusion: The global burden of CLD and cirrhosis is substantial. Although vaccination, screening, and anti-viral treatment campaigns for hepatitis B and C have reduced CLD burden in some parts of the world, concomitant increases in injection drug use, alcohol misuse and metabolic syndrome threaten these trends. Ongoing efforts to address CLD-related morbidity and mortality require accurate contemporary estimates of epidemiology and outcomes.

Subfields: Hepatology, Pathology and Forensic Medicine

View Paper: https://www.semanticscholar.org/paper/42d6ea05f7360c4d1d2579fc5f80ae47c3baaad2

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