The role of ROS in tumour development and progression
By E. Cheung, Karen H. Vousden. Nature Reviews. Cancer, 2022
1,314 citations recorded by the source corpus.
Eukaryotic cells have developed complex systems to regulate the production and response to reactive oxygen species (ROS). Different ROS control diverse aspects of cell behaviour from signalling to death, and deregulation of ROS production and ROS limitation pathways are common features of cancer cells. ROS also function to modulate the tumour environment, affecting the various stromal cells that provide metabolic support, a blood supply and immune responses to the tumour. Although it is clear that ROS play important roles during tumorigenesis, it has been difficult to reliably predict the effect of ROS modulating therapies. We now understand that the responses to ROS are highly complex and dependent on multiple factors, including the types, levels, localization and persistence of ROS, as well as the origin, environment and stage of the tumours themselves. This increasing understanding of the complexity of ROS in malignancies will be key to unlocking the potential of ROS-targeting therapies for cancer treatment. Reactive oxygen species (ROS) are highly reactive molecules derived from oxygen during cellular metabolism, which regulate various cell phenotypes. In this Review, Cheung and Vousden outline how pathways controlling ROS production and limitation can contribute to tumorigenesis and how the complexities in the responses of both cancer cells and stromal components to ROS might determine the success or failure of ROS modulating therapies.
Subfields: Biotechnology, Cancer Research, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/42b2efb7b42310ddbfddd7f780139a0f54c05ead
How researchers see this paper
The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.
In Molecular Biology
Citations in the corpus
- Targeting cell death pathways for cancer therapy: recent developments in necroptosis, pyroptosis, ferroptosis, and cuproptosis research (2022, background): “Furthermore, excessive proliferation of tumor cells is always accompanied by high ROS production, but these cells optimize ROS-driven proliferation via their effective antioxidant activity, enabling them to adapt and thrive under highly oxidative conditions while preventing ROS from reaching that th”
- Targeting p53 pathways: mechanisms, structures and advances in therapy (2023, background): “Increased levels of reactive oxygen species in tumor cells have a dual effect, both by promoting the acquisition of a tumor phenotype and by activating ROS-dependent death signals to kill tumor cells.(111,112) The regulation of ROS by p53 also has a dual function.”
- Mitochondria in oxidative stress, inflammation and aging: from mechanisms to therapeutic advances (2025, neutral): “39 On the one hand, ROS facilitates tumor development by inducing mutations in some genes by oxidizing DNA.”