The chemistry of Cas9 and its CRISPR colleagues

By Janice S. Chen, Jennifer A. Doudna. 2017

122 citations recorded by the source corpus.

Subfields: Molecular Biology

View Paper: https://www.semanticscholar.org/paper/429607b8436fee4aaf682e7f221d23ea1c18f145

How researchers see this paper

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In Molecular Biology

1. Dima Kozakov
2. John Karanicolas
3. Matthieu Wyart
4. Carolina Brito
5. Riccardo Ravasio
6. Le Yan
7. Chung-Jung Tsai
8. P. Hamm

Citations in the corpus

• Point-of-care CRISPR/Cas nucleic acid detection: Recent advances, challenges and opportunities (2020, unknown): “TracrRNA (green) is essential for target sequence recognition and target sequence cleavage, as well as the association between the crRNAs and Cas effector protein (Chen and Doudna, 2017).”
• Allostery in Its Many Disguises: From Theory to Applications (2019, methodology): “Mutating two of these residues (K775A and R905A) was shown to decrease off-target cleavage of partially complementary DNAs (Chen and Doudna, 2017), opening an avenue for modulating the activity of CRISPR-Cas9 systems.”