Clinical significance of intercellular contact at the four-cell stage of human embryos, and the use of abnormal cleavage patterns to identify embryos with low implantation potential: a time-lapse…

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Ethical Implementation of Artificial Intelligence to Select Embryos in In Vitro Fertilization (2021, background): “However, the availability of numerous data points made available by recent advances, such as with time-lapse videography [10], has enabled novel parameters to be measured for embryo selection [11, 12, 13].”
Between-laboratory reproducibility of time-lapse embryo selection using qualitative and quantitative parameters: a systematic review and meta-analysis (2020, methodology): “Examples of these parameters include (i) direct cleavage (DC) where one blastomere directly divides into three or more daughter blastomeres [11], (ii) reverse cleavage (RC) where blastomeres either fuse after cleavage or lead to failed cytokinesis following karyokinesis [12], (iii) chaotic cleavage ”
Assessing efficacy of day 3 embryo time-lapse algorithms retrospectively: impacts of dataset type and confounding factors (2019, background): “…patient or culture conditions between laboratories, are considered to contribute to the poor transferability of developed algorithms (Barrie et al., 2017; Best, Campbell, Duffy, Montgomery, & Fishel, 2013; Freour et al., 2015; Liu et al., 2015; Petersen et al., 2016; Yalcinkaya et al., 2014).”