Liquid biopsy: monitoring cancer-genetics in the blood

By E. Crowley, Federica Di Nicolantonio, F. Loupakis, A. Bardelli. Nature Reviews Clinical Oncology, 2013

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Origins, structures, and functions of circulating DNA in oncology (2016, background): “[33], Ba single diploid human cell contains 6 pg of DNA and there is a median of 17 ng of DNA/mL of plasma in advanced-stage cancers;”
Liquid biopsy: a step closer to transform diagnosis, prognosis and future of cancer treatments (2022, background): “Thus, LB provides enhanced sensitivity in diagnosis and ease of repeated sampling throughout treatment in a much more convenient and non-invasive way [6].”
RNA-Seq of Tumor-Educated Platelets Enables Blood-Based Pan-Cancer, Multiclass, and Molecular Pathway Cancer Diagnostics (2015, neutral): “Companion Diagnostics Tumor Tissue Biomarkers Are Reflected by Surrogate TEP mRNA Onco-signatures Blood provides a promising biosource for the detection of companion diagnostics biomarkers for therapy selection (Bettegowda et al., 2014; Crowley et al., 2013; Papadopoulos et al., 2006).”