Non-Smad pathways in TGF-β signaling

By Ying E. Zhang. Cell Research, 2009

1,646 citations recorded by the source corpus.

Transforming growth factor-β utilizes a multitude of intracellular signaling pathways in addition to Smads to regulate a wide array of cellular functions. These non-canonical, non-Smad pathways are activated directly by ligand-occupied receptors to reinforce, attenuate, or otherwise modulate downstream cellular responses. These non-Smad pathways include various branches of MAP kinase pathways, Rho-like GTPase signaling pathways, and phosphatidylinositol-3-kinase/AKT pathways. This review focuses on recent advances in the understanding of the molecular and biochemical mechanisms of non-Smad pathways. In addition, functions of these non-Smad pathways are also discussed.

Subfields: Molecular Biology

View Paper: https://www.semanticscholar.org/paper/426620734eec72599c4f6b9b79b273cb3e69e3bd

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In Molecular Biology

1. David A. Baker
2. Y. Hao
3. P. ten Dijke

Citations in the corpus

• TGF-β-Mediated Epithelial-Mesenchymal Transition and Cancer Metastasis (2019, background): “Non-SMAD signaling can also be initiated directly downstream of the TGF-β receptor by activation of various branches of the MAP kinase (MAPK) pathway, Rho-like GTPase signaling pathways and the phosphatidylinositol-3-kinase (PI3K)/AKT pathway [22].”